Myeloid has dosed its first patient in the IMAGINE study, which is a Phase 1/2, multicenter, open-label, dose-escalation and dose cohort expansion clinical trial evaluating MT-101 in patients with refractory or relapsed PTCL. The dose-escalation portion of this Phase 1 study, with and without conditioning therapy, is open and enrolling patients.  Once Myeloid establishes the recommended Phase 2 dose, a Phase 2 trial will be initiated to support registration in this patient population.

MT-101 is being developed for the treatment of relapsed and refractory CD5-expressing T cell lymphomas. Refractory PTCL is a lethal disease with limited treatment options, that until now has not benefited from innovations in cell therapy. In vitro and in vivo studies show MT-101 demonstrated meaningful anti-tumor activity. Treatment in these models has been associated with potent phagocytosis responses, the production of inflammatory mediators and delays in tumor progression.  

Please visit www.clinicaltrials.gov (NCT05138458) for additional information.

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Patients

 We are actively recruiting patients to participate in clinical trials.  If you or your loved one has Peripheral T cell Lymphoma please see more information about the study below:

MT-101 IMAGINE Phase 1/2 Study