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Research Associate/Sr. Research Associate, RNA & Molecular Biology

Posting Date:

June 3, 2021

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Department at Myeloid:

Molecular RNA Science

Position Type:

Full-Time

Myeloid Therapeutics is seeking a Research Associate/Sr. Research Associate in RNA and Molecular Biology. You will contribute to the assay development and execution for therapeutic mRNAs to support company’s pre-clinical and clinical efforts. In addition, you will contribute to the process development for in vitro transcription, modification and purification of long RNA molecules and produce RNAs and help with the company efforts to improve the RNA expression of in myeloid cells. We seek applicants that are proactive, enthusiastic, and show a passion for drug discovery. The applicant should have strong communication and collaboration skills, along with a strong technical background in nucleic acid biology and production. Strong attention to details and excellent organizational and documentation skills are highly desirable.

 

Key Responsibilities

  • Execute and troubleshoot standard protocols, develop and adapt new protocols, and query literature to incorporate additional assays as needed

  • Contribute to the RNA production process optimization to simplify manufacturing, decrease cost and/or improve characteristics of drug substance 

  • Synthesize, purify, and characterize drug substance 

  • Contribute to the development and execution of the analytical testing supporting process development and drug substance characterization

  • Independently plan and execute experiments

  • Perform data analysis and trending

  • Deliver reproducible and impactful results under ambitious timelines 

  • Maintain thorough electronic lab notebooks and documentation records

  • Adhere to all laboratory safety requirements and procedures, assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering and receiving of lab supplies

  • Create and write analytical reports and SOPs to support development and regulatory filings

  • Document all experimental planning and progress in electronic lab notebook, prepare PowerPoint slides and present your finding to multi-disciplinary teams

 

Qualifications:

  • Bachelors to MS in Biochemistry, Molecular Biology, Chemistry, or related discipline with 2-5 years of laboratory experience

  • Previous experience with analytical technologies including qPCR, RT-qPCR, ELISA, capillary electrophoresis, HPLC 

  • Strong laboratory skills in synthesis, purification, and characterization of RNA

  • Experience with optimization of enzymatic and chemical reactions

  • Previous hands-on support for process development and scale-up of drug substance including synthesis and purification of nucleic acids

  • Previous experience with mammalian cell culture is preferred

  • Previous experience with nanoparticle formulations and characterizations, mixing technologies, and tangential flow filtration is a plus

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